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面临通过用减毒的病毒人工感染产生的免疫新模型,改变着的病毒感染生态学需要继续再评论。最近麻疹在美国再次发生流行对研究先前曾接种疫苗的人群发生麻疹提供机会。尽管在社会流行时判断疫苗功效有困难,现有的麻疹病毒疫苗已经显示非常有效。已经发现先前曾接种疫苗的儿童经常发生亚临床型再感染。已有文献证明在一些先前曾接种疫苗的儿童中有被第二次抗体反应证明的临床型再感染。已经提示活疫苗接种后变症或非典型麻疹的可能性,但证据尚不足。用进一步减毒活疫苗在低抗体滴度情况下进行再接种,已表示是可能的,但仅两组儿童曾被指出需要再接种,即曾在未满11个月龄时接种的儿童和接种灭活疫苗的儿童。
Faced with a new model of immunity by artificial infection with an attenuated virus, altered viral infection ecology needs to be revisited. The recent re-emergence of measles in the United States provides an opportunity to study measles in previously vaccinated populations. While there is difficulty in judging the efficacy of vaccines in times of social epidemic, existing measles virus vaccines have been shown to be very effective. It has been found that subclinical reinfection frequently occurs in previously vaccinated children. It has been documented that there are clinical re-infections proven by the second antibody response in some previously vaccinated children. The possibility of post-vaccination post-vaccination or atypical measles has been suggested, but the evidence is insufficient. Re-vaccination with a live attenuated vaccine at low antibody titers has been shown to be possible, but only two groups of children have been identified as needing re-vaccination, ie vaccinated children and vaccinated at less than 11 months of age Inactivated vaccine for children.