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观察在离心机高Ｇ值反复作用下，血脑屏障通透性的变化特点，为高Ｇ值作用下脑功能改变的解释提供生理学依据．方法：选雄性大鼠２０只，分为对照组及＋Ｇｚ暴露后不同时间组，实验组经增长率为１Ｇ／ｓ，持续３ｍｉｎ的＋１０Ｇｚ暴露３次，立即经大鼠心脏灌注镧固定液，开颅取脑，制成切片，置透射电镜下观察．结果：＋Ｇｚ重复暴露３次后即刻，即见镧颗粒通过少数开放的毛细血管内皮细胞间的紧密连接，沉积于血管外围；暴露后１ｈ及６ｈ，可见大部分毛细血管内皮细胞间的紧密连接开放，镧颗粒弥漫性地分布于神经细胞间隙，部分镧颗粒已进入神经细胞内部，分布于线粒体、内质网等细胞器的表面；暴露后２４ｈ，则见镧颗粒仅局限分布在血管腔内，毛细血管外的间隙则未见镧颗粒沉积，与对照组大鼠相似．结论：＋１０Ｇｚ／３ｍｉｎ重复作用３次可引起大鼠血脑屏障通透性增加，这种改变是可逆的．其可能在＋Ｇｚ致脑水肿的发生、发展过程中起重要作用．
To observe the changes of the permeability of the blood-brain barrier under the repeated high G value of the centrifuge and to provide the physiological basis for the explanation of the changes of brain function under the effect of high G value. Methods: Twenty male rats were randomly divided into control group and different time groups after + Gz exposure. The experimental group was exposed to +10 Gz for 3 times with a growth rate of 1G / s. The rats were immediately perfused with lanthanum fixing solution Cranial brain, made into slices, placed under transmission electron microscopy. Results: Immediate exposure of + Gz after 3 repeated exposures showed that lanthanum particles were deposited on the periphery of blood vessels through the tight connection between a few open capillary endothelial cells. At 1 h and 6 h after exposure, most of the capillary endothelial cells showed tight junctions , Lanthanum particles diffusely distributed in the nerve cell gap, part of the lanthanum particles have entered the nerve cells, distributed in mitochondria, endoplasmic reticulum and other organelles surface; 24 hours after exposure, then see lanthanum particles only localized in the vascular cavity, capillary There was no deposition of lanthanum particles in the extravascular space, similar to the control rats. CONCLUSION: Repeated action of + 10Gz / 3min for 3 times can cause an increase of blood-brain barrier permeability in rats, and this change is reversible. It may play an important role in the development of brain edema induced by + Gz.