In order to avoid the interference to the primary user(PU), in this paper Cognitive Radio (CR) periodically senses the presence of PU, and during one period, CR can sense all the sub-channels based on weighed data fusion and then use all the idle channels decided by the coordinator. The local sensing time of CR is divided into multi-slots in which CR can sense any sub-channel. Through reasonably allocating the sensing slots and users by mathematic optimization, the proposed algorithm can improve the total throughput of CR. The optimization problem of the proposed scheme which seeks to maximize the throughput subject to the constraint of the detected performance of each sub-channel is proposed in order to choose the optimum local sense time and the number of the cooperative CRs. The simulation results indicate that the proposed scheme can obtain higher throughput than the conventional single-channel sense, and there are the optimum local sense time and the number of cooperative CRs to make the throughput reach maximum. In order to avoid the interference to the primary user (PU), in this paper Cognitive Radio (CR) periodically senses the presence of PU, and during one period, CR can sense all the sub-channels based on weighed data fusion and then use all the idle channels decided by the coordinator. The local sensing time of CR is divided into multi-slots in which CR can sense any sub-channel. Through reasonably allocating the sensing slots and users by mathematic optimization, the proposed algorithm can improve the total throughput of CR. The optimization problem of the throughput scheme to the constraint of the detected performance of each sub-channel is proposed in order to choose the optimum local sense time and the number of the cooperative CRs. The simulation results indicate that the proposed scheme can obtain higher throughput than the conventional single-channel sense, and there are the optimum local sense time and the number of cooperative CRs to m ake the throughput reach maximum.