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目的观察缬沙坦对高血压病患者蛋白尿定量的影响。方法将132例高血压伴蛋白尿患者随机分为两组,对照组给予依那普利治疗,治疗组在对照组基础上加用缬沙坦治疗,比较两组患者24h尿蛋白定量的变化。结果两组治疗3个月后24h尿蛋白定量较治疗前明显下降,差异有统计学意义(P<0.05),治疗组效果优于对照组(P<0.05)。两组治疗前后血肌酐及血钾水平差异无统计学意义(P>0.05)。结论在ACEI类药物治疗基础上加用缬沙坦可以进一步减少高血压病患者尿蛋白的排泄作用。
Objective To observe the effect of valsartan on proteinuria in patients with essential hypertension. Methods 132 cases of hypertensive patients with proteinuria were randomly divided into two groups. The control group was given enalapril. The treatment group was treated with valsartan on the basis of the control group. The 24-hour urinary protein in the two groups was compared. Results The urinary protein in 24 hours after treatment was significantly lower than that before treatment in 3 months (P <0.05), and the effect of treatment group was better than that of control group (P <0.05). Before and after treatment, serum creatinine and serum potassium levels had no significant difference (P> 0.05). Conclusions The addition of valsartan to ACEIs can further reduce the excretion of urinary protein in hypertensive patients.