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建立了激光散射法测定帕博昔布原料药的粒径及其分布。采用Malvern Mastersizer 3000型激光粒度分析仪,Hydro MV湿法进样器。帕博昔布在水中易团聚,需加入适当的分散剂来促进粒子在水中的均匀分散。设定参数为:搅拌速度2 000 r/min,遮光度10%~17%,背景与样品的测量时间10 s,样品折射率1.48,吸光率0.01。该法准确、简便、重复性好,可用于帕博昔布原料药的粒径分析。
A laser scattering method was established for the determination of the particle size and distribution of the raw materials of the drug. A Malvern Mastersizer 3000 laser particle size analyzer, Hydro MV wet sampler was used. Bocubacter easily reunite in water, the need to add appropriate dispersants to promote the uniform dispersion of particles in water. Setting parameters: stirring speed 2000 r / min, shading 10% ~ 17%, background and sample measurement time 10 s, sample refractive index 1.48, absorbance 0.01. The method is accurate, simple and reproducible, and can be used for the particle size analysis of the raw materials of the drug.