循环内皮细胞(CEC)检测能在活体内研究血管内皮细胞(VEC)的变化,具有较高的临床应用价值,但其来源尚待研究,尤其缺乏从VEC过渡到CEC的直接证据。本文采用人脐静脉内皮细胞培养等手段,对CEC的来源进行了比较细致的研究。结果表明:(1)存在于正常人外周血中的CEC来源于正常代谢过程中脱落的VEC;(2)本文获得了从VEC过渡到CEC的直接证据;(3)CEC的形成是一渐变过程。 The detection of circulating endothelial cells (CEC) can study the changes of vascular endothelial cells (VECs) in vivo, which has a high clinical value. However, its origin is yet to be studied. In particular, there is no direct evidence of the transition from VEC to CEC. In this paper, human umbilical vein endothelial cell culture and other means, the source of CEC conducted a more detailed study. The results showed that: (1) CECs in normal human peripheral blood originated from VEC shedding in normal metabolism; (2) direct evidence of the transition from VEC to CEC was obtained; (3) CEC formation was a gradual change .