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目的:探讨胃幽门螺杆菌(Hp)感染与颈动脉斑块的相关性。方法:利用ELISA对100例无胃炎无胃溃疡病史的急性脑梗塞患者进行Hp细胞毒素抗体检测,分Hp感染阴性组和阳性组,比较颈动脉斑块及颈动脉狭窄的发生率,比较相关因子C-反应蛋白、血脂、白细胞的变化水平,进行统计学处理。结果:Hp细胞毒素阳性者,颈动脉斑块发生率100%,阴性55%(P<0.01),相关因子阳性组明显高于阴性组(P<0.05)。结论:Hp细胞毒素感染与颈动脉斑块发生、发展有密切关系,应当予以积极治疗与预防。
Objective: To investigate the correlation between Helicobacter pylori (Hp) infection and carotid artery plaque. Methods: Hp cytotoxin antibody was detected in 100 cases of acute cerebral infarction without gastritis and without gastric ulcer by ELISA. The incidence of carotid artery plaque and carotid artery stenosis were compared between Hp infection negative group and positive group. The relative factors C-reactive protein, blood lipids, leukocyte levels, for statistical analysis. Results: The positive rate of Hp cytotoxin was 100% in carotid plaque and 55% in negative (P <0.01), and the positive rate in related factor was significantly higher than that in negative group (P <0.05). Conclusion: Hp cytotoxin infection is closely related to the occurrence and development of carotid plaque, and should be actively treated and prevented.