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目的：检测乳腺癌组织中多药耐药基因的表达并探讨其与ER，PR以及预后的关系。方法：采用S－P免疫织化方法，对120倒乳腺癌组织进行P糖蛋白（PgP），ER／PR表达的检测。结果：乳腺癌组织中P糖蛋白阳性表达为33.3％，ER阳性表达51．7％，PR阳性表达37.5％。P糖蛋白与乳腺癌组织类型及ER／PR天关，PgP，ER／PR阳性表达均与乳腺病预后有关（P＜0.01）。结论：PgP，EE／PR三个指标估计乳腺癌预后比单一指标为好。
Objective: To detect the expression of multidrug resistance gene in breast cancer tissues and to explore its relationship with ER, PR and prognosis. Methods: The P-glycoprotein (PgP) and ER/PR expression were detected in 120 inverted breast cancer tissues by S-P immunohistochemistry. Results: The positive expression of P glycoprotein in breast cancer tissues was 33.3%, the positive expression of ER was 51.7%, and the positive expression of PR was 37.5%. P-glycoprotein and breast cancer tissue types and ER/PR days, PgP, ER/PR positive expression were related to the prognosis of breast disease (P<0.01). Conclusion: The three indicators of PgP and EE/PR are better than the single index in estimating the prognosis of breast cancer.