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目的研究肝细胞癌(HCC)中Survivin的表达及其与临床指标的关系。方法应用免疫组织化学SP法检测HCC组织及相应癌旁组织Survivin蛋白的表达,TUNEL法检测细胞凋亡指数(AI)。结果 75%的肝癌组织表达Survivin蛋白,而癌旁及正常肝癌组织内均阴性表达。阳性表达率与肝内转移(42.9%和92.3%)、门静脉癌栓形成(47.1%和95.7%)及肿瘤大小(89.3%和47.1%)有关;30例Survivin表达阳性癌组织的AI为(1.558±0.628)%,显著低于Survivin表达阴性癌组织(4.738±0.954)%,(P<0.05)。结论 Survivin可能通过对凋亡的抑制而参与肝癌发生、发展。
Objective To investigate the expression of Survivin in hepatocellular carcinoma (HCC) and its relationship with clinical parameters. Methods The expression of Survivin protein in HCC tissue and adjacent normal tissues was detected by immunohistochemical SP method. The apoptosis index (AI) was detected by TUNEL method. Results Survivin protein was expressed in 75% of HCC tissues and negatively in both adjacent and normal HCC tissues. The positive expression rate was related to intrahepatic metastasis (42.9% and 92.3%), portal vein thrombosis (47.1% and 95.7%) and tumor size (89.3% and 47.1%), respectively. The AI of the 30 cases with positive Survivin expression was (1.558 ± 0.628)%, which was significantly lower than that of Survivin negative (4.738 ± 0.954)% (P <0.05). Conclusion Survivin may participate in the development and progression of hepatocarcinoma through the inhibition of apoptosis.