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目前,在世界范围内蔓延的获得性免疫缺陷综合征(AIDS),是由于控制机体免疫反应中枢的辅助T淋巴细胞受到人类免疫缺陷病毒(HIV)的感染,而被破坏,从而导致免疫功能低下,10～30%感染者发生机会感染,而多致死亡的一种疾病。作为治疗药物,已发表的有,可有阻碍HIV 逆转录酶的HPA—23及叠氮胸腺嘧啶脱氧核苷(AZT)等,有报道认为AZT 有延长AIDS 患者生命的效果。另一方面,已知道,中药之一甘草的有效成分甘草酸(GL)对于疱疹病毒具有抗病毒作用,本文就GL 对HIV 的增殖是否具有抑制作用这一问题进行了探讨。其结果表明,GL 对HIV 的细胞内增殖是有抑制作用的。材料和方法
At present, Acquired Immune Deficiency Syndrome (AIDS) that spreads around the world is caused by destruction of the helper T-lymphocytes that control the body’s immune response center and is caused by human immunodeficiency virus (HIV), resulting in low immune function. , 10 to 30% of infected persons have opportunistic infections and a disease that causes death. As therapeutic drugs, HPA-23 and AZT, which inhibit HIV reverse transcriptase, have been reported, and AZT has been reported to have an effect of prolonging the lives of AIDS patients. On the other hand, it is known that glycyrrhizic acid (GL), one of the active ingredients of Glycyrrhiza uralensis, has an antiviral effect on herpes viruses. This article discusses whether GL has an inhibitory effect on the proliferation of HIV. The results show that GL has an inhibitory effect on the intracellular proliferation of HIV. Materials and Method