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自1977年Laverty在电镜中观察到宫颈癌活检组织中存在HPV颗粒,以及Zur Hausen提出人乳头瘤病毒(humanpapillomavirus,HPV)与宫颈癌发病相关联的假设后,国内外学者对此问题进行了大量的研究,最终在1995年的IARC专题讨论会上通过HPV感染是宫颈癌的主要原因,即HPV感染是关键和必要的致病因素。宫颈癌发病缓慢,存在明确的前期病变,即宫颈上皮内瘤样变(cervical intraepithelial neo-plasia,CIN),从HPV感染到宫颈癌发病历时数年到十几年。在发达国家,由于宫颈癌前病变的筛查和治疗,宫颈癌的发
Since Laverty’s observation of the presence of HPV particles in cervical cancer biopsies by electron microscopy in 1977 and the hypothesis that Zur Hausen proposed the association of human papillomavirus (HPV) with the development of cervical cancer, domestic and foreign scholars have done a lot of work on this issue Of HPV infections are the leading cause of cervical cancer eventually culminating in the IARC Colloquium 1995, where HPV infection is the key and necessary causative agent. The incidence of cervical cancer is slow, there is a clear pre-lesion, that cervical intraepithelial neo-plasia (CIN), from HPV infection to cervical cancer incidence of several years to a dozen years. In developed countries, due to cervical precancerous lesions screening and treatment of cervical cancer hair