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目的探讨人工流产与中国女性乳腺癌发病风险的关系,为我国人群慎重选择人工流产术及乳腺癌的预防提供科学可信的依据。方法通过检索中国知网学术期刊全文数据库、万方数据库、维普数据库和文献追溯等方法,收集国内公开发表的关于人工流产与中国女性乳腺癌相关的病例对照研究文献。采用Meta(荟萃)分析方法计算人工流产与中国女性乳腺癌的合并效应值OR及其95%的可信区间(95%CI)。结果共检索到257篇文献,依照纳入标准和剔除标准,最终19篇相关文献被纳入。根据异质性分析结果(P<0.001,I2=86%),选择随机效应模型。Meta分析结果显示,人工流产与中国女性乳腺癌的合并效应值OR=1.59,95%CI:1.30~1.94,P<0.001。根据人工流产的次数进行亚组分析,与无人工流产史相比,人工流产1次、≥2次的合并效应值OR及95%CI分别为1.01(0.93~1.10)和1.69(1.25~2.29)。结论人工流产是中国女性乳腺癌的危险因素,多次人工流产术可增加罹患乳腺癌的风险。
Objective To explore the relationship between induced abortion and the risk of breast cancer in Chinese women and to provide a scientific and credible basis for the Chinese population to choose induced abortion and prevent breast cancer. Methods The domestic published literature on case-control study on induced abortion and breast cancer in Chinese women were collected through searching the full-text database of Chinese academic journals, Wanfang database, VIP database and literature review. Meta (meta) analysis was used to calculate the combined effect of induced abortion and Chinese female breast cancer OR and its 95% confidence interval (95% CI). Results A total of 257 articles were retrieved. Based on the inclusion criteria and the exclusion criteria, the final 19 related articles were included. Random effects models were selected based on heterogeneity (P <0.001, I2 = 86%). Meta analysis showed that the combined effect of induced abortion and Chinese female breast cancer was OR = 1.59, 95% CI: 1.30-1.94, P <0.001. According to the number of induced abortion, the OR and 95% CI of the first and second degree of abortion were 1.01 (0.93-1.10) and 1.69 (1.25-2.29), respectively, compared with those without abortion. . Conclusions Induced abortion is a risk factor for breast cancer in Chinese women. Repeated abortion may increase the risk of breast cancer.