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对１９例临床确认为颞叶癫痫而行海马杏仁核及皮层病灶切除术棘波灶的标本进行了电镜观察，发现在病变神经元周围，有髓神经纤维髓板松解、融合，轴突出芽；无髓神经纤维内微丝、微管排列紊乱，缠绕成团，见团样小体结构；突触中圆形突触小泡增多或耗竭。扁平状突触小泡相对较少；神经毡及毛细血管旁可见许多颗粒性电子致密物沉着，经Ｘ射线显微分析排除无机离子，考虑这些沉着物仍为机体的有机成份。半定量观察结果显示三个部位超微病理变化具有相似性。本课题的观察提示神经纤维及突触的病变可能是痫性活动的直接形态依据，而这种具有病变神经纤维及突触的神经元在痫性活动中则可能起着“起搏细胞”的作用，痫性活动的产生与兴奋性及抑制性递质的平衡失调有关。
Electron microscopy was performed on 19 specimens of temporal lobe epilepsy, which were treated by resection of the hippocampal amygdala and cortical lesions of the spine. Electron microscopy was performed on the specimens of diseased neurons. The myelinated fibers of the myelinated nerve fibers were released and fused, ; Unmyelinated fibers within the microfilaments, microtubules arranged in disorder, wound into a group, see the group-like body structure; synapses in the round synaptic vesicles increased or depleted. Flat synaptic vesicles are relatively small; many foci of granular electron dense material are visible on the nerve felts and capillaries, and inorganic ions are excluded by X-ray microanalysis, considering that these deposits are still the organic components of the body. Semi-quantitative observation results show that the three parts of the ultrastructure pathological changes have similarities. The observation of this subject suggests that the pathological changes of nerve fiber and synapse may be the direct morphological basis of epileptic activity. However, neurons with diseased nerve fibers and synapses may play a role of “pacemaker” in epileptic activity Role, the production of epileptic activity and excitability and inhibitory transmitter balance disorders.