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Flt3配体 (FL)是新近发现的、具有促进早期造血功能的细胞因子。在再生障碍性贫血、骨髓抑制等一系列造血功能障碍病变时 ,血清FL浓度升高。FL是评价造血功能的可靠指标之一。FL单用或与其它细胞因子联合应用 ,可以有效地扩增造血干 /祖细胞 ,增加定向造血干 /祖细胞及除红系以外的各系血细胞。FL可有效地激发造血干 /祖细胞进入细胞周期 ,因此 ,对以造血干 /祖细胞为靶细胞的基因治疗具有重要意义。最近的研究还发现 ,由于对树突状细胞、自然杀伤细胞及细胞毒T淋巴细胞的刺激效应 ,FL在体内具有显著的抗肿瘤作用。
Flt3 ligands (FLs) are newly discovered and have cytokines that promote early hematopoiesis. In aplastic anemia, bone marrow suppression and a series of hematopoietic disorders, serum FL concentration increased. FL is a reliable indicator of hematopoietic function. FL alone or in combination with other cytokines, can effectively expand hematopoietic stem / progenitor cells, hematopoietic stem / progenitor cells and hematopoietic cells in addition to other than the Department of red blood cells. FL can effectively stimulate hematopoietic stem / progenitor cells into the cell cycle, therefore, the hematopoietic stem / progenitor cells target gene therapy is of great significance. Recent studies have also found that FL has a significant anti-tumor effect in vivo due to its stimulatory effect on dendritic cells, natural killer cells and cytotoxic T lymphocytes.