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目的总结过氧化物酶体增殖物激活受体γ(PPARγ)激动剂抗转化生长因子-β(TGF-β)促器官纤维化作用的研究进展。方法复习有关PPARγ激动剂抗TGF-β促器官纤维化作用的文献并进行综述。结果 TGF-β是一种主要的促纤维化细胞因子,能促进多种器官的纤维化进程,而PPARγ激动剂则可以有效地阻断TGF-β的信号传导,从而发挥抗器官纤维化的作用。结论研究PPARγ激动剂主要通过阻断TGF-β信号传导来实现抗器官纤维化的机理,有助于PPARγ激动剂在临床上的推广运用,为治疗器官纤维化疾病提供一种新途径。
Objective To summarize the research progress of peroxisome proliferator - activated receptor γ (PPARγ) agonist against transforming growth factor - β (TGF - β) in promoting organ fibrosis. Methods The literature review on PPARγ agonist anti-TGF-β-induced organ fibrosis was reviewed and reviewed. Results TGF-β was a major pro-fibrogenic cytokine that promoted fibrosis in many organs. However, PPARγ agonists effectively blocked TGF-β signaling and thus played a role in resistance to organ fibrosis . CONCLUSION: PPARγ agonists can prevent organ fibrosis through blocking TGF-β signaling and contribute to the clinical application of PPARγ agonists. It provides a new approach for the treatment of organ fibrosis.