异丙肾上腺素(ISP)可明显升高子宫cAMP水平,此作用可被心得安能完全拮抗。在去极化小鼠子宫中,ISP升高cAMP的作用与外Ca~(2+)浓度呈反相关系。利血平化后,ISP作用明显增强。提示ISP引起小鼠子宫松驰作用,可能与其激动β受体从而升高cAMP有关;ca~(2+)与cAMP间有互相拮抗作用,而利血平化后,ISP作用增强可能与此时子宫平滑肌β受体对外源性激动剂效应增敏有关。 Isoproterenol (ISP) can significantly increase uterine cAMP levels, this effect can be completely antagonized propranolol. In the depolarized mouse uterus, the effect of ISP on increasing cAMP was inversely related to the concentration of exogenous Ca 2+. After reserpine, ISP role was significantly enhanced. Suggesting that ISP induced mouse uterine relaxation, may be related to its activation of β receptors and thus increase cAMP; ca ~ (2+) and cAMP mutual antagonism, and reserpine, the role of ISP may be enhanced at this time Uterine smooth muscle β receptor on the exogenous agonist effect sensitization.