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目的:探讨淋巴管生成因子LYVE-1及Prox-1的定量表达与宫颈癌淋巴结转移的相关性。方法:收集宫颈鳞癌手术标本24例,运用半定量RT-PCR技术对淋巴管生成因子LYVE-1和Prox-1进行分析,分别比较这两种因子在切除标本的肿瘤组织、癌旁组织中表达的差异。结果:Prox-1在肿瘤及癌旁组织表达分别为1.52±0.26和0.46±0.19,LYVE-1在肿瘤及癌旁正常组织的表达分别为1.37±0.21和0.56±0.12。Prox-1及LYVE-1在肿瘤组织的表达均高于癌旁组织(P均<0.01),与肿瘤的发生有关。并且它们的表达与淋巴结转移有相关性(P<0.01)。结论:Prox-1及LYVE-1表达升高与宫颈癌发生及淋巴结转移有一定关系,检测该指标对了解宫颈癌的侵袭和转移具有一定价值。
Objective: To investigate the relationship between the expression of lymphangiogenic factors LYVE-1 and Prox-1 and lymph node metastasis in cervical cancer. Methods: Twenty-four cervical squamous cell carcinoma specimens were collected and the lymphangiogenesis factors LYVE-1 and Prox-1 were analyzed by semi-quantitative RT-PCR. The expressions of Pro-1 and LYVE-1 were compared between the tumor tissues and adjacent tissues Differences in expression. Results: The expression of Prox-1 was 1.52 ± 0.26 and 0.46 ± 0.19 respectively in tumor and paracancerous tissues, and the expression of LYVE-1 in tumor and paracancerous tissues was 1.37 ± 0.21 and 0.56 ± 0.12 respectively. The expression of Prox-1 and LYVE-1 in tumor tissues were significantly higher than those in adjacent tissues (all P <0.01), which were related to tumorigenesis. And their expression was correlated with lymph node metastasis (P <0.01). Conclusion: The elevated expression of Prox-1 and LYVE-1 has some relationship with the occurrence of cervical cancer and lymph node metastasis. Detecting this index has some value in understanding the invasion and metastasis of cervical cancer.