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室温条件下,发展了一种串联高效、高选择性地构建官能团化的饱和γ-丁内酯的新方法.实验表明,以易得的炔烃衍生物和4-戊烯酸为底物,Pd Cl2为催化剂,Cu Cl2?2H2O为氧化剂,离子液体[C2O2mim]Cl为溶剂,无添加配体的情况下,以中等及优良的产率(69%~93%)合成了系列官能团化的饱和γ-丁内酯衍生物.其结构均经1H NMR、13C NMR、MS及HRMS确证.该方法具有反应条件温和、底物适用范围广、环境友好等优点,为含饱和γ-丁内酯结构单元的天然产物及复杂药物分子的合成提供了一种新途径.
Under room temperature, a new method of constructing functionalized saturated γ-butyrolactone in series with high efficiency and high selectivity has been developed. The experimental results show that, using readily available alkyne derivatives and 4-pentenoic acid as substrate, PdCl 2 as catalyst, Cu Cl 2 · 2H 2 O as oxidant and ionic liquid [C 2 O 2 mim] Cl as solvent, a series of functional groups were synthesized with moderate and excellent yield (69% ~ 93%) without adding ligand γ-butyrolactone and its structure were confirmed by 1H NMR, 13C NMR, MS and HRMS.The method has the advantages of mild reaction conditions, wide range of substrate application, environmental friendliness, Unit of natural products and the synthesis of complex drug molecules provides a new way.