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近来我们应用重组人肿瘤坏死因子(TNF)瘤体内注射治疗肿瘤24例。效果显著,现报告如下。 1 材料和方法病例选择:本组均为经病理检查确诊的恶性肿瘤病人。其中原发性肝癌4例,颈淋巴结转移癌4例,直肠癌3例,结肠癌、胃癌肝转移、外阴癌、腮腺癌、软腭癌、鼻咽癌、喉癌、胸膜间皮瘤、胃腺癌、食管癌、乳腺癌、横纹肌肉瘤、平滑肌肉瘤各1例。TNF由上海第二军医大学微生物学教研室提供。本制剂2ml 1支,含100万单位TNF。治疗方法:瘤体内和肿瘤基底部注射,每次2～4ml(根据瘤体大小而定),每周2次。多数病人用到8～10ml,最多1例用到20ml。瘤体直径超过
Recently, we used recombinant human tumor necrosis factor (TNF) tumor injection to treat 24 cases of tumor. The effect is significant. The report is as follows. 1 Materials and Methods Case Selection: This group was diagnosed with malignant tumors by pathological examination. There were 4 cases of primary liver cancer, 4 cases of cervical lymph node metastases, 3 cases of rectal cancer, colon cancer, gastric cancer liver metastases, vulvar cancer, parotid gland carcinoma, soft palate cancer, nasopharyngeal carcinoma, laryngeal cancer, pleural mesothelioma, and gastric adenocarcinoma. , esophageal cancer, breast cancer, rhabdomyosarcoma, leiomyosarcoma in 1 case each. TNF is provided by the Department of Microbiology, Shanghai Second Military Medical University. The preparation 2ml 1 contains 1000000 units of TNF. Treatment method: intratumoral and tumor base injection, each 2 ~ 4ml (according to the size of the tumor), 2 times per week. Most patients use 8 to 10 ml and up to 1 to 20 ml. Tumor diameter exceeds