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目的:检测喉鳞状细胞癌组织中IL-17的表达情况,评价IL-17的表达在喉鳞状细胞癌生物学行为和预后中的价值。方法:采用免疫组化SP法检测71例喉鳞状细胞癌及21例癌旁组织中IL-17的表达。结果:喉鳞状细胞癌组织中IL-17的表达率为54.9%(39/71),与癌旁组织(28.6%)对比差异有统计学意义(P<0.05);IL-17的表达与喉癌的分期、肿瘤分化、区域淋巴结转移、远处转移及复发有关(均P<0.05);Log-rank检验显示患者预后与肿瘤原发灶部位、原发灶分期、区域淋巴结转移、远处转移、IL-17的表达有关(P<0.05),多因素Cox回归分析发现IL-17不是影响患者预后的独立危险因素。结论:IL-17与喉鳞状细胞癌的发生、发展以及预后关系密切,是喉鳞状细胞癌患者的不良预后因素,可为喉鳞状细胞癌的抗肿瘤免疫治疗提供一定的理论依据。
Objective: To detect the expression of IL-17 in laryngeal squamous cell carcinoma and to evaluate the value of IL-17 expression in the biological behavior and prognosis of laryngeal squamous cell carcinoma. Methods: Immunohistochemical SP method was used to detect the expression of IL-17 in 71 cases of laryngeal squamous cell carcinoma and 21 cases of paracancerous tissues. Results: The expression of IL-17 in laryngeal squamous cell carcinoma was 54.9% (39/71), which was significantly different from that in adjacent non-cancerous tissues (28.6%) (P <0.05) (P <0.05). Log-rank test showed that the prognosis was related to the location of primary tumor, primary tumor staging, regional lymph node metastasis, distant lymph node metastasis, distant metastasis and lymph node metastasis (P <0.05). Multivariate Cox regression analysis revealed that IL-17 was not an independent risk factor for the prognosis of patients. CONCLUSION: IL-17 is closely related to the occurrence, development and prognosis of laryngeal squamous cell carcinoma, which is a poor prognostic factor for laryngeal squamous cell carcinoma and may provide some theoretical basis for anti-tumor immunotherapy of laryngeal squamous cell carcinoma.