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背景:长期使用类固醇激素容易引起股骨头缺血性坏死,中药鹿茸具有骨生长因子,能促进伤口愈合、组织修复,可能对股骨头缺血性坏死具有治疗作用。目的:观察鹿茸粉对大鼠激素诱导性股骨头缺血性坏死的治疗作用。方法:将42只雄性wistar大鼠分成空白对照组、模型组和高、中、低剂量治疗组。1周2次臀部肌肉注射给予地塞米松(30mg/kg),连续6周。高、中、低剂量治疗组按200,400,800mg/kg剂量灌胃鹿茸粉,每天1次,空白对照组、模型组给予同量生理盐水。治疗2个月后,测量大鼠血脂水平,取两侧股骨头测量骨密度、病理变化及血管内皮细胞生长因子表达。结果与结论:类固醇激素干预后,大鼠造成明显股骨头缺血性坏死损伤,经过治疗后高、中、低剂量治疗组大鼠损伤骨组织明显恢复,与模型组相比,骨密度增高,总胆固醇、三酰甘油和低密度脂蛋白水平下降,股骨血管内皮细胞生长因子表达上升。提示鹿茸粉能通过增加骨形成,改善脂肪代谢和增加血管形成来治疗激素诱导性股骨头坏死。
BACKGROUND: Long-term use of steroid hormones can easily cause avascular necrosis of femoral head. Chinese pilose antlers have bone growth factors, which can promote wound healing and tissue repair and may have therapeutic effect on avascular necrosis of femoral head. Objective: To observe the therapeutic effect of antler powder on hormone-induced avascular necrosis of the femoral head in rats. Methods: Forty-two male wistar rats were divided into blank control group, model group and high, medium and low dose treatment groups. 2 times a week intramuscular injection of dexamethasone (30mg / kg) for 6 weeks. The high, middle and low dose treatment groups were treated with 200,400,800mg / kg antler powder once a day. The blank control group and model group were given the same amount of saline. After 2 months of treatment, the level of blood lipid in the rats was measured. The bone mineral density (BMD), pathological changes and the expression of vascular endothelial growth factor were measured by measuring the femoral head on both sides. RESULTS AND CONCLUSION: After steroid hormone intervention, the rats had obvious avascular necrosis of the femoral head. After treatment, the damaged bone tissues of rats in the high, medium and low dose treatment groups recovered obviously. Compared with the model group, the bone mineral density increased, Total cholesterol, triglyceride and low density lipoprotein levels decreased, and femoral vascular endothelial cell growth factor expression increased. Tip antler powder can increase hormonal induced osteonecrosis by increasing bone formation, improving fat metabolism and increasing blood vessel formation.