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目的探讨肺表面活性物质治疗新生儿胎粪吸入综合征的疗效。方法对商丘市第四人民医院收治的胎粪吸入综合征患儿100例,随机分为观察组和对照组各50例,对照组给予常规治疗,观察组在接受常规窒息抢救外,还接受肺表面活性物质的治疗,将两组患儿呼吸机使用的时间、住院天数以及死亡率进行对比。结果观察组呼吸机使用时间为(4±1.2)d,对照组呼吸机使用时间为(6±1.3)d。统计学检验,差异有可比性(t=7.99,P<0.01)。观察组住院天数为(17.2±3.2)d,对照组住院天数为(29.6±10.4)d。统计学检验,差异有可比性(t=8.06,P<0.01)。观察组患儿死亡率为8.0%,对照组为24.0%,经统计学检验,差异具有统计学意义(χ2=9.52,P<0.01)。结论肺表面活性物质能有效减少呼吸机使用的时间、住院天数以及降低死亡率。在临床上值得推广。
Objective To investigate the efficacy of pulmonary surfactant in the treatment of neonatal meconium aspiration syndrome. Methods 100 cases of meconium aspiration syndrome admitted to the Fourth People’s Hospital of Shangqiu City were randomly divided into observation group and control group with 50 cases in each group. The control group was given routine treatment. The observation group received routine asphyxia rescue, Surfactant treatment, the two groups of children with ventilator time, hospital days and mortality were compared. Results The use of ventilator in the observation group was (4 ± 1.2) days and in the control group was (6 ± 1.3) days. Statistical tests, the difference was comparable (t = 7.99, P <0.01). The days of hospitalization in observation group were (17.2 ± 3.2) days, and those in control group were (29.6 ± 10.4) days. Statistical test, the difference was comparable (t = 8.06, P <0.01). The mortality rate in the observation group was 8.0% and that in the control group was 24.0%. The difference was statistically significant (χ2 = 9.52, P <0.01). Conclusion Pulmonary surfactant can effectively reduce the time of ventilator use, days of hospitalization and reduce the mortality rate. In clinical worth promoting.