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目的 探讨T细胞免疫核糖核酸 (iRNA)是否可以通过调节机体免疫功能而影响关节炎病理生理过程 ,为类风湿关节炎治疗探索一条新路。方法 利用大鼠佐剂性关节炎 (AA)动物模型 ,腹腔注射T细胞免疫核糖核酸 ,观察关节体积、关节指数及关节病理变化。结果 注射 10d后 ,关节体积、关节指数与关节炎对照组比较差异均有显著性 (P <0 0 5 ) ,病理结果显示滑膜组织增生及炎症细胞浸润均较关节炎对照组明显减轻。结论 T细胞iRNA调节免疫系统功能抑制关节炎病理生理过程 ,其机制可能是iRNA通过诱生大量细胞因子的作用。
Objective To investigate whether T cell immune ribonucleic acid (iRNA) can affect the pathophysiological process of arthritis by regulating immune function and explore a new approach for the treatment of rheumatoid arthritis. Methods The rat model of adjuvant arthritis (AA) was induced by intraperitoneal injection of T lymphocytes. The joint volume, joint index and pathological changes of joints were observed. Results After 10 days of injection, the joint volume and joint index were significantly different from those of the arthritis control group (P <0.05). The pathological results showed that the synovial tissue proliferation and infiltration of inflammatory cells were significantly reduced compared with the arthritis control group. Conclusion T cell iRNA regulates immune system function and inhibits the pathophysiology of arthritis. Its mechanism may be that iRNA induces a large number of cytokines.