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随着人们生活水平的提高,糖尿病(特别是2型糖尿病)患者有迅速增长的趋势。视网膜、肾、神经等组织并发症的发生是糖尿病患者致残和致死的主要原因。严格控制糖尿病患者的血糖可以有效地预防各种并发症的发生与发展。目前临床实验室检测用于监测血糖浓度的常用指标有空腹血糖、餐后2h血糖、糖化血清蛋白(GSP)、糖化血红蛋白(HbA1c)、糖化清蛋白(GA)等。GA是近年来提出的对糖尿病患者血糖监测的新指标。现就GA的生理特性、检测方法、检测方法的影响因素、临床应用及研究进展做一简要综述。1 GA的生理特性GA是血中葡萄糖与血浆中清蛋白发生非酶促反应的产
As people’s living standards improve, patients with diabetes (especially type 2 diabetes) have a rapidly increasing trend. Retina, kidney, nerve and other tissue complications of disability and death of diabetic patients is the main reason. Strict control of diabetic patients with blood glucose can effectively prevent the occurrence and development of various complications. At present, the commonly used indicators for monitoring blood glucose levels in clinical laboratory tests are fasting blood glucose, postprandial blood glucose 2h, glycosylated serum protein (GSP), glycosylated hemoglobin (HbA1c), glycated albumin (GA) and so on. GA is proposed in recent years, a new indicator of glucose monitoring in diabetic patients. Now on the physiological characteristics of GA, detection methods, detection methods of influencing factors, clinical application and research progress to make a brief review. 1 The physiological characteristics of GA GA is a non-enzymatic reaction of glucose and plasma albumin