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目的 探讨细胞黏附分子在肺癌组织中的表达及其与转移和预后的关系。方法 通过免疫组化的方法检测 42例肺癌组织中CD44v6和CEA表达的情况 ,并分析这些因子的表达与肺癌转移及预后的关系。结果 肺癌组织中CD44v6和CEA的阳性表达率分别为 6 9%和 5 2 %。CD44v6的表达与肺癌的临床分期和淋巴结转移呈正相关 (P <0 0 5 ) ,与术后生存时间呈负相关 (P <0 .0 5 )。CEA的表达与肺癌的临床分期、淋巴结转移及术后生存期无关 (P >0 .0 5 )。结论 CD44v6与肺癌的发生发展有密切关系 ,它可作为肺癌一种新的肿瘤标记物
Objective To investigate the expression of cell adhesion molecules in lung cancer and its relationship with metastasis and prognosis. Methods The expression of CD44v6 and CEA in 42 cases of lung cancer was detected by immunohistochemistry. The relationship between the expression of these factors and the metastasis and prognosis of lung cancer was analyzed. Results The positive rates of CD44v6 and CEA in lung cancer tissues were 69% and 52%, respectively. The expression of CD44v6 was positively correlated with the clinical stage and lymph node metastasis (P <0.05), but negatively correlated with the survival time (P <0.05). The expression of CEA was not associated with the clinical stage, lymph node metastasis and postoperative survival of lung cancer (P> 0.05). Conclusion CD44v6 is closely related to the occurrence and development of lung cancer. It can be used as a new tumor marker for lung cancer