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目的:探讨慢性牙周炎患者与其口腔中的幽门螺杆菌(helicobacter pylori,HP)的相关性。方法:依据HP特异的尿素酶C和cagA基因设计引物,建立PCR方法。检测37例牙周炎患者口腔菌斑和含漱液中的HP,同时设立牙周健康对照组,比较两组的检测结果。结果:尿素酶C基因在牙周炎组的阳性率为64.8%,健康组为38.5%;尿素酶C基因和cagA基因共同阳性率在牙周炎组为32.4%,健康组为7.7%;两组差异有统计学意义;且轻型牙周炎患者口腔HP阳性率低于中、重型患者。龈下菌班HP阳性率高于龈上菌斑。结论:HP参与了慢性牙周炎的致病过程,抑或是加强了其它因素的致病过程,HP与牙周炎有相关性。
Objective: To investigate the correlation between helicobacter pylori (HP) and oral cavity in patients with chronic periodontitis. Methods: According to HP specific urease C and cagA gene designed primers, PCR method was established. The HP in oral plaque and gargle of 37 patients with periodontitis was detected. At the same time periodontal healthy control group was established, and the test results of two groups were compared. Results: The positive rate of urease C gene was 64.8% in periodontitis group and 38.5% in healthy group. The common positive rate of urease C gene and cagA gene was 32.4% in periodontitis group and 7.7% in healthy group. Group differences were statistically significant; and the positive rate of oral HP in patients with light periodontitis was lower than that in medium and heavy patients. Subgingival bacterial HP positive rate than the supragingival plaque. Conclusion: HP is involved in the pathogenic process of chronic periodontitis, or is to strengthen the pathogenic process of other factors, HP is associated with periodontitis.