约100年前,1887年9月20日,一名24岁的妇女在费城医院接受了William Osler对其神经性疾病的治疗。该病表现为身体的不同部分——手或手指、膝盖、肘、臀部、胳膊或大腿的多肉部分、面部及单独在唇部出现慢性周期性短暂水肿发作。Osler未推测病因,但确定是遗传性。从病人92岁的祖父了解到这一家族五 About 100 years ago, on September 20, 1887, a 24-year-old woman underwent William Osler’s treatment for her neurological illness at the Philadelphia Hospital. The disease manifests itself in different parts of the body - the fleshy part of the hands or fingers, the knees, the elbows, the buttocks, the arms or the thighs, the face and the chronic periodic epileptic seizures of the face and lips alone. Osler did not speculate on the cause but decided hereditary. The family is learned from the 92-year-old grandfather of the patient