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在查明先天性疾病的发生和原因中,配子疾病的研究具有特殊意义。一些导致先天性病理状态产生的因素中,配子的过熟或衰老,特别受重视。因此,在目前分析人类先天性疾病原因时,集中注意了上述问题。总结积累的资料,可以把配子的衰老看作是在生育过程障碍时或在生理条件下产生的普遍现象。过熟(衰老)是指受精前、不同类型动物的某一不同间期(受精期)期满后,配子内发生的综合变化。衰老过程是女性或男性生殖细胞所固有的。然而,在发生早期发育障碍中,女性生殖细胞的衰老意义巨大。已
In identifying the occurrence and causes of congenital diseases, the study of gametogenesis has special significance. Some of the factors that contribute to the congenital pathological conditions are particularly important for gametes that are overmature or aging. Therefore, in the current analysis of the causes of human congenital diseases, attention has been given to the above problems. Summarizing the accumulated data, we can consider the aging of gametes as a common phenomenon that occurs during the process of childbirth or under physiological conditions. Over-ripening (aging) refers to the combined changes that occur in gametes after the expiration of a different interval (fertilization period) of different types of animals before fertilization. Senescence is inherent in female or male germ cells. However, the aging of female germ cells is of great significance in the event of early developmental disorders. Already