促红细胞生成素是一种多功能细胞因子,中枢神经系统已被证实可产生促红细胞生成素及其受体,实验证明促红细胞生成素具有多种神经保护作用。本文阐述了促红细胞生成素在中枢神经系统的表达与信号转导途径,及其通过血脑屏障的机制,并重点就蛛网膜下腔出血后的神经保护作用和缓解脑血管痉挛的作用及机制进行综述。 Erythropoietin is a multifunctional cytokine that has been shown to produce erythropoietin and its receptors in the central nervous system. Experiments show that erythropoietin has several neuroprotective effects. This article describes the expression of erythropoietin in the central nervous system and signal transduction pathways, and its mechanism through the blood-brain barrier, focusing on the neuroprotective effect after subarachnoid hemorrhage and relieve the role of cerebral vasospasm and mechanism For review.