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角膜病是我国主要的致盲眼病之一,其临床诊疗水平的提高有赖于基础与应用基础研究的深度与广度。我国在角膜病的基础与应用基础研究的某些领域已处于国际先进水平。但是总体来说,目前我国角膜病的基础研究与发达国家仍存在较大差距,具体体现在缺乏系统性研究、研究经费有限、从事研究人员的素质与数量均不够等方面。今后我国的角膜病基础研究应主要集中在感染性角膜病的发病机制、角膜营养不良的致病基因、角膜的组织工程、干眼的发病机制、严重眼表化学伤的组织重建、眼表新生血管的发病机制与预防、移植排斥反应的治疗药物开发等方面。争取研究经费、培养高素质人才及加强国内外和不同学科间的合作是提高我国角膜病基础研究的重要工作。
Corneal disease is one of the major causes of blindness in our country. The improvement of clinical diagnosis and treatment depends on the depth and breadth of fundamental and applied basic research. In some areas of basic research and application of corneal disease, our country has been at the advanced international level. But generally speaking, there is still a big gap between the basic research on corneal diseases and the developed countries in our country. The concrete manifestation is the lack of systematic research, the limited research funding and the insufficient qualifications and quantity of researchers. In the future, the basic research of corneal disease in our country should mainly focus on the pathogenesis of infectious corneal disease, pathogenic genes of corneal malnutrition, tissue engineering of cornea, pathogenesis of dry eye, tissue remodeling of serious ocular chemical injury, ocular surface renaissance Vascular pathogenesis and prevention, transplant rejection drug development and other aspects. Fighting for funding for research, training high-quality personnel and strengthening cooperation at home and abroad with different disciplines are important tasks in improving the basic research on corneal diseases in our country.