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作者用免疫荧光法观察了攻膜复合物(Membrane Attack Complex,MAC)及IgG、IgA、IgM、C_3在正常及40例各种病理类型肾小球肾炎的肾组织中的分布。正常肾小球内仅在系膜区发现少量的MAC的沉积,但是肾小球肾炎的肾组织中,随着病理改变的加重,MAC的沉积增加,从单纯沉积于系膜区扩大到毛细血管壁,甚至在包曼氏囊及肾小球基底膜中也可发现。我们还注意到随着MAC在肾小球内沉积的增多、尿中蛋白量高,同时基底膜上阴离子电荷消失增多,提示肾小球肾炎肾组织的损伤与MAC直接相关。
The author used immunofluorescence method to observe the distribution of Membrane Attack Complex (MAC) and IgG, IgA, IgM and C_3 in normal and glomerulonephritis of 40 pathological types. In normal glomeruli, only a small amount of MAC deposition was found in the mesangial area, but in the glomerulonephritis kidney tissue, the deposition of MAC increased with the increase of the pathological changes, from simple deposition in the mesangial area to capillary The wall, even in the bag Man’s sac and glomerular basement membrane can also be found. We also noticed that with the increase of deposition of MAC in glomeruli, the high amount of urinary protein and the disappearance of anionic charge in basement membrane suggest that the damage of renal tissue in glomerulonephritis is directly related to MAC.