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目的了解抗HCV治疗对HCV/HIV混合感染者白细胞及CD4细胞的影响。方法回顾分析本科收治的12例HCV/HIV混合感染者在抗HCV治疗过程中白细胞及CD4细胞变化情况。结果 12例接受PEG-IFNα-2a联合利巴韦林抗病毒治疗者,均出现不同程度的白细胞及CD4细胞计数的减少。其中同时使用含有齐多夫定的HAART方案者白细胞及CD4细胞计数减少最为明显。结论对于HCV/HIV混合感染者,在抗HCV治疗过程中应密切注意白细胞及CD4细胞的变化,抗HCV治疗前应尽可能更换含有齐多夫定片的HAART治疗方案。
Objective To understand the effects of anti-HCV treatment on leucocytes and CD4 cells in HCV / HIV co-infected patients. Methods Retrospective analysis of 12 cases of undergraduate HCV / HIV infection in anti-HCV treatment of leukocytes and CD4 cells changes. Results In 12 patients receiving PEG-IFNα-2a combined with ribavirin antiviral therapy, there were different degrees of leukocyte and CD4 cell count reduction. Among them, the reduction of leukocyte and CD4 cell count was the most obvious when using HAART with zidovudine. Conclusion For HCV / HIV co-infected patients, we should pay close attention to the changes of white blood cells and CD4 cells in the course of anti-HCV treatment. The treatment of HAART with zidovudine tablets should be replaced as much as possible before anti-HCV treatment.