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目的：研究胃腺癌的血管内皮细胞生长因子（ｖａｓｃｕｌａｒ ｅｎｄｏｔｈｅｌｉａｌ ｃｅｌｌ ｇｒｏｗｔｈ ｆａｃｔｏｒ， ＶＥＧＦ）及其受体 ＫＤＲ（ＶＥＧＦＲ）的表达，并探讨其临床意义。方法：应用免疫组织化学染色法检测ＶＥＧＦ／ＶＥＧＦＲ的表达，并分析其与６１例胃腺癌临床病理特征之间的关系。结果：胃腺癌组织ＶＥＧＦ／ＶＥＧＦＲ的阳性表达率分别为５５．９％和３９．３％；其中粘液腺癌和管状腺癌表达率较高（Ｐ＜０．０５，Ｐ＜０．０１），ＶＥＧＦ／ＶＥＧＦＲ表达率分别为７１．４Ｔ／４２．８％和６１．９％／５２．４％；ＶＥＧＦ／ＶＥＧＦＲ的阳性表达与ＴＮＭ分期有显著差异（Ｐ＜０．０５，Ｐ＜０．０１），阳性率为Ⅵ＞Ⅲ＞Ⅱ＞Ⅰ期，Ⅳ、Ⅲ、Ⅱ、Ⅰ期的表达率分别为 ８０．０％／５０．０％，６８．２％／４５．５％，４０．０％／３０．０％和３６．８％／３１． ６％；胃腺癌并转移患者，ＶＥＧＦ／ＶＥＧＦＲ的阳性表达分别为７６．２％和４７．６％，远高于无转移的４５．０％和３５．０％（Ｐ＜０．０５，Ｐ＜０．０１）；术后生存期小于１年的ＶＥＧＦ的表达率为６６．７％，明显高于术后生存期１年以上的５２．２％。结论：ＶＥＧＦ是胃腺癌血管生成的正向调
Objective: To study the expression of vascular endothelial cell growth factor (VEGF) and its receptor KDR (VEGFR) in gastric adenocarcinoma and its clinical significance. Methods: The expression of VEGF/VEGFR was detected by immunohistochemical staining, and the relationship between the expression of VEGF/VEGFR and clinicopathological features of 61 cases of gastric adenocarcinoma was analyzed. Results: The positive rates of VEGF/VEGFR in gastric adenocarcinoma were 55.9% and 39.3%, respectively. The expression rates of mucinous adenocarcinoma and tubular adenocarcinoma were higher (P<0.05, P<0.01). The expression rates of VEGF/VEGFR were 71.4T/42.8% and 61.9%/52.4%, respectively; the positive expression of VEGF/VEGFR was significantly different from TNM staging (P<0.05, P<0.01). The positive rate was VI>III>II>I phase, and the expression rates of IV, III, II, and I phase were 80.0%/50.0%, 68.2%/45.5%, 40.0 respectively. %/30.0% and 36.8%/31. 6%; gastric adenocarcinoma metastasis patients, VEGF / VEGFR positive expression were 76.2% and 47.6%, far higher than the non-metastasis 45.0% and 35.0% (P <0.05, P <0.01); The postoperative survival period of less than 1 year of VEGF expression rate was 66.7%, significantly higher than the postoperative survival period of more than 1 year of 52.2%. Conclusion: VEGF is a positive regulation of angiogenesis in gastric adenocarcinoma