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目的:观察左旋氧氟沙星(LVFX)在胆道手术后患者的胆药浓度及其影响因素。方法:13例施行胆道手术并行T-管引流的患者poLVFX200mg,q8h,连服5d,用HPLC法测定LVFX在血浆、胆汁中的药物浓度。结果:胆囊结石降低胆汁中药物浓度;胆道梗阻程度与胆汁药物浓度有密切相关性,梗阻程度愈高,药物浓度愈低。结论:胆道疾病(特别是结石性胆道疾病)所造成的胆道梗阻状态在很大程度上影响LVFX在胆道的浓度,梗阻状态下低胆汁药物浓度将不利于感染的治疗。
Objective: To observe the concentration of levofloxacin (LVFX) in patients after biliary tract surgery and its influencing factors. Methods: Thirteen patients underwent T-tube drainage of poLVFX for biliary tract surgery for 200 mg and q8 h for 5 days. The drug concentrations of LVFX in plasma and bile were determined by HPLC. Results: Gallstones reduced the drug concentration in bile. The degree of biliary obstruction was closely related to the concentration of bile drug. The higher the degree of obstruction, the lower the drug concentration. CONCLUSIONS: The condition of biliary obstruction caused by biliary tract diseases (especially stone diseases of biliary tract) largely influences the concentration of LVFX in the biliary tract. In the obstructive state, the biliary drug concentration is not conducive to the treatment of infection.