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目的观察依那普利联合氨氯地平治疗高血压病的临床疗效。方法高血压患者120例,随机均分为两组:A组每天联合口服依那普利10mg和氨氯地平5mg治疗;B组给予依那普利10mg/d单药治疗。治疗24周后,比较两组疗效和相关不良反应。结果与治疗前相比,两组治疗24周后,收缩压和舒张压均有下降(P<0.01);治疗后,A组收缩压和舒张压均低于B组[(132.3±7.4)mmHg vs.(138.3±8.3)mmHg和(85.8±8.2)mmHg vs.(89.7±7.4)mmHg](P<0.01)。与治疗前相比,两组治疗24周后,血糖和三酰甘油均有升高(P<0.05);治疗后,A组血糖高于B组,三酰甘油低于B组(P<0.05)。与治疗前相比,A组治疗24周后AST水平下降,B组AST水平升高(P<0.05);治疗后,A组AST低于B组(P<0.05)。两组治疗相关不良反相仿,均较轻微,对症处理后缓解。结论依那普利联合氨氯地平治疗高血压的效果优于单药依那普利,不增加不良反应。
Objective To observe the clinical efficacy of enalapril combined with amlodipine in the treatment of hypertension. Methods One hundred and twenty patients with hypertension were randomly divided into two groups: group A was treated with oral enalapril 10mg and amlodipine 5mg daily; group B was given enalapril 10mg / d monotherapy. After 24 weeks of treatment, the efficacy and adverse reactions of the two groups were compared. Results Compared with those before treatment, systolic and diastolic blood pressure decreased after 24 weeks of treatment in both groups (P <0.01). After treatment, systolic and diastolic blood pressure in group A were lower than those in group B [(132.3 ± 7.4) mmHg vs. (138.3 ± 8.3) mmHg and (85.8 ± 8.2) mmHg vs. (89.7 ± 7.4) mmHg] (P <0.01). Compared with those before treatment, blood glucose and triglyceride were increased in both groups after 24 weeks of treatment (P <0.05); after treatment, blood glucose in group A was higher than that in group B, and triglyceride was lower than that in group B (P <0.05 ). Compared with those before treatment, AST decreased in group A and AST in group B after 24 weeks of treatment (P <0.05). After treatment, AST in group A was lower than that in group B (P <0.05). Two groups of treatment-related adverse reaction imitation, are minor, symptomatic treatment after remission. Conclusion The effect of enalapril combined with amlodipine in the treatment of hypertension is superior to that of enalapril alone, with no adverse reactions.