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目的 分析利巴韦林与α-IFN治疗偏肺病毒(metapneiimovirus,MPV)感染引起的小儿毛细支气管炎的临床治疗指标及疗效的影响.方法 选取2010年8月-2015年8月于就诊的210例偏肺病毒感染引起的小儿毛细支气管炎患者,按照随机数字表法分为三组:对照组(n=70)采用激素、支气管扩张等常规方法治疗;利巴韦林组(n=70)采用传统治疗方法伴以利巴韦林静点治疗;α-IFN组(n=70)采用传统治疗方法伴以α-IFN肌注治疗,两两比较不同组别的临床治疗指标及疗效的情况.结果 利巴韦林组及α-IFN组与对照组相比,在咳嗽、喘息、肺部罗音消失时间和住院天数明显缩短(P＜0.05).利巴韦林组及α-IFN组与对照组相比,总有效率提高显著(P＜0.05).结论 利巴韦林与α-IFN在治疗偏肺病毒感染引起的小儿毛细支气管炎上,具有改善临床治疗指标、提高总有效率的作用.“,”Objective To analyze the effect of ribavirin and a-IFN in treatment of children with bronchiolitis caused by metapneumovirus infection.Methods 210 cases of children with bronchiolitis caused by metapneumovirus infection admitted to our hospital from August 2010 to August 2015 were selected as research objects and they were randomly divided into three groups:the control group (n =70) were treated with conventional methods such as hormone therapy and bronchodilatation.The ribavirin group (n =70) were treated with conventional methods as well as ribavirin.The α-IFN group (n =70) were treated with conventional methods as well as α-IFN.The Clinical therapeutic index and effect of different groups were compared.Results Cough,wheezing,pulmonary rales and hospitalization time of the ribavirin group and α-IFN group were significantly shorter than the control group (P ＜ 0.05).There was no differences between the the ribavirin group and α-IFN group.The total effective rates of the ribavirin group and α-IFN group were significantly improved than the control group (P ＜ 0.05).Conclusions In the treatment of children with bronchiolitis caused by metapneumovirus infection,ribavirin and α-IFN has the function of improving the clinical therapeutic index and improving the total effective rates.