肝细胞癌(HCC)是已发现肿瘤中最常见的类型之一,尤其在亚洲和非洲。肝炎B或C病毒感染、慢性肝炎和肝再生被认为是HCC重要的危险因素,但有关这些因素在HCC发生中的作用还不清楚。在许多人类癌症发生中,肿瘤抑制基因突变造成的功能丢失是非常重要的。在肿瘤细胞中,肿瘤抑制基因的突变以及相关正常等位基因的随后丢失可通过特异的染色体或 Hepatocellular carcinoma (HCC) is one of the most common types found in tumors, especially in Asia and Africa. Hepatitis B or C virus infection, chronic hepatitis, and liver regeneration are considered important risk factors for HCC, but the role of these factors in the development of HCC is unclear. In many human cancers, loss of function due to tumor suppressor mutations is very important. In tumor cells, mutations in tumor suppressor genes and subsequent loss of related normal alleles can be through specific chromosomes or