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目的探讨非洛地平联合阿托伐他汀治疗老年单纯收缩期高血压的临床疗效及应用价值。方法回顾性分析2015年12月—2016年12月170例老年单纯收缩期高血压患者的临床资料,根据治疗方法不同分为观察组和对照组,对照组给予非洛地平治疗,观察组给予联合阿托伐他汀治疗,对比两组治疗效果。计量资料比较采用t检验,P<0.05为差异有统计学意义。结果观察组治疗后收缩压(134.18±5.41)mm Hg,舒张压(78.94±2.11)mm Hg,脉压差(60.09±1.78)mm Hg;对照组治疗后收缩压(137.74±5.52)mm Hg,舒张压(65.28±1.13)mm Hg,脉压差(71.74±3.87)mm Hg,组间对比差异有统计学意义(P<0.05)。观察组治疗后甘油三酯(2.18±0.54)mmol/L,总胆固醇(4.35±0.64)mmol/L,低密度脂蛋白(2.77±0.19)mmol/L;对照组治疗后甘油三酯(3.12±1.01)mmol/L,总胆固醇(5.28±1.05)mmol/L,低密度脂蛋白(3.32±0.68)mmol/L,组间对比差异有统计学意义(P<0.05)。结论非洛地平联合阿托伐他汀应用在老年单纯收缩期高血压可以有效改善患者血压,有助于降低脉压差,同时能够辅助降低患者血脂浓度,具有良好的应用价值。
Objective To investigate the clinical efficacy and clinical value of felodipine combined with atorvastatin in elderly patients with isolated systolic hypertension. Methods The clinical data of 170 elderly patients with isolated systolic hypertension were retrospectively analyzed from December 2015 to December 2016. The patients were divided into observation group and control group according to different treatment methods. The control group was treated with felodipine. The observation group was given combined treatment Atorvastatin treatment, compared two groups of treatment. Measurement data were compared using t test, P <0.05 for the difference was statistically significant. Results After treatment, systolic blood pressure (134.18 ± 5.41) mm Hg, diastolic blood pressure (78.94 ± 2.11) mm Hg and pulse pressure difference (60.09 ± 1.78) mm Hg in the observation group were significantly lower than those in the control group (137.74 ± 5.52 mm Hg, Diastolic pressure (65.28 ± 1.13) mm Hg, pulse pressure difference (71.74 ± 3.87) mm Hg, the difference between the two groups was statistically significant (P <0.05). After treatment, triglyceride (2.18 ± 0.54) mmol / L, total cholesterol (4.35 ± 0.64) mmol / L and low density lipoprotein 1.01) mmol / L, total cholesterol (5.28 ± 1.05) mmol / L and low density lipoprotein (3.32 ± 0.68) mmol / L respectively. There was significant difference between the two groups (P <0.05). Conclusion The application of felodipine combined with atorvastatin in elderly patients with isolated systolic hypertension can effectively improve blood pressure, help to reduce the pulse pressure difference, and at the same time can help reduce the patient’s blood lipid concentration, and has good application value.