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目的观察短期联合阿司匹林(ASA)和氯吡格雷(CPG)抗栓治疗对急性进展性缺血性卒中发生率的影响。方法入选新发急性非心源性缺血性卒中患者100例,随机分为联合抗栓组(ASA联合CPG)51例和标准治疗组(ASA联合安慰剂)49例,分别测评患者入院时及入院后1周的美国国立卫生研究院卒中量表(NIHSS)评分,比较两组间进展性卒中的发生率。结果两组在基线资料方面无差异,联合抗栓组发生进展2例,标准治疗组发生进展5例,两组间进展性卒中发生率差异显著(P<0.05)。结论短期联合抗栓治疗可以降低急性进展性缺血性卒中的发生率。
Objective To observe the effects of short-term aspirin (ASA) and clopidogrel (CPG) antithrombotic therapy on the incidence of acute progressive ischemic stroke. Methods One hundred and fifty new patients with acute non-cardiac ischemic stroke were randomly divided into combined antithrombotic group (ASA combined with CPG) 51 cases and standard treatment group (ASA combined with placebo) 49 cases, were measured on admission and The National Institutes of Health Stroke Scale (NIHSS) score at 1 week after admission compared the incidence of progressive stroke between the two groups. Results There was no difference in the baseline data between the two groups. There were 2 cases in the combined antithrombotic group and 5 cases in the standard treatment group. The incidence of progressive stroke was significantly different between the two groups (P <0.05). Conclusion Short-term combined antithrombotic therapy can reduce the incidence of acute progressive ischemic stroke.