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分别用免疫印迹法、免疫胶乳法、放射免疫法测定了５６例慢性丙型肝炎患者的７种ＥＮＡ多肽抗体、类风湿因子及二种甲状腺抗体（ＴＭ、ＴＧ）。发现慢性丙肝患者血清中有多种自身抗体，其中以抗－ｕ１ＲＮＰ、抗－ＳＳ－Ａ二种ＥＮＡ多肽抗体、ＲＦ的检出率最高。７５％（４２例）丙肝患者血清中可检测到一种以上的自身抗体。在丙肝病毒复制指标ＨＣＶ－ＲＮＡ阴转后，自身抗体检出率明显下降，说明在慢性丙型肝炎存在与ＨＣＶ复制有关的自身免疫现象，这有助于进一步揭示其发病机理。
Seven kinds of ENA peptide antibody, rheumatoid factor and two kinds of thyroid antibody (TM, TG) were determined in 56 patients with chronic hepatitis C by immunoblotting, immuno-latex and radioimmunoassay respectively. Found in patients with chronic hepatitis C serum a variety of autoantibodies, including anti-u1RNP, anti-SS-A two ENA polypeptide antibodies, RF detection rate was highest. More than one autoantibody can be detected in 75% (42) of hepatitis C patients. The detection rate of autoantibodies was significantly decreased after HCV-RNA was reversed by hepatitis C virus replication, indicating that autoimmunity associated with HCV replication exists in chronic hepatitis C, which may help to further reveal its pathogenesis.