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本文应用酶联火箭电泳法测定了９０例各种肝病的血清胎盘酸性同工铁蛋白（ＰＡＩＦ）。结果表明，原发性肝癌（ＰＨＣ）的ＰＡＩＦ（５１１．７９±４８４．９２ｎｇ／ｍｌ）显著高於肝炎（２５９．３８±１４３．４３ｎｇ／ｍｌｐ＜０．００５）及肝良性占位性病变（５８．７５±４５．８８ｎｇ／ｍｌｐ＜０．０５），诊断敏感性６９．２３％，特异性８６．８９％，可靠性８０％。小肝癌（直径≤５ｃｍ）检出率８０％，ＡＦＰ阴性ＰＨＣ的阳性率８５．７１％，５例ＰＨＣ治疗前后ＰＡＩＦ对比有显著性差异（ｐ＜０．０５）。同步测定９０例肝病血清常规铁蛋白（ＳＦ）的结果显示，对ＰＨＣ的诊断阳性率７９．４９％，特异性６５．９１％，可靠性６５．９％。二种血清铁蛋白的测定在ＰＨＣ诊断中均可取，尤其在ＡＦＰ阴性时，对小肝癌治疗的监测也具有一定临床参考价值，但ＰＡＩＦ的测定在ＰＨＣ诊断中优于ＳＦ。ｐ＜０．００１以ＳＦ≥３００ｎｇ／ｍｌ，ＰＡＩＦ≥３００ｎｇ／ｍｌ为诊断ＰＨＣ的判别值，各组结果见表２。ＳＦ及ＰＡＩＦ诊断ＰＨＣ的敏感性、特异性、可靠性、假阳性、假阴性分别为：７９．４９％、６９．２３％、６５．９１％、８６．８９％、６５．９％及８０％、４７．７３％、１?
In this paper, the serum placental acid isoferritin (PAIF) in 90 cases of various liver diseases was determined by enzyme-linked rocket electrophoresis. The results showed that PAIF in primary liver cancer (PHC) was significantly higher than that in hepatitis (259.38±143.43 ng/mlp<0.005) and benign liver lesions (511.79±484.92 ng/ml). 58.75±45.88 ng/ml p<0.05), the diagnostic sensitivity was 69.23%, specificity 86.89%, and reliability 80%. The detection rate of small hepatocellular carcinoma (≤5cm in diameter) was 80%, and the positive rate of AFP-negative PHC was 85.71%. There was a significant difference (P<0.05) in the comparison of PAIF before and after treatment in 5 cases of PHC. The results of simultaneous determination of serum ferritin (SF) in 90 cases of liver disease showed that the positive rate of PHC was 79.49%, specificity was 65.91%, and reliability was 65.9%. The determination of two serum ferritin can be taken in the diagnosis of PHC, especially when AFP is negative, it has certain clinical reference value for monitoring the treatment of small hepatocellular carcinoma, but the determination of PAIF is better than SF in the diagnosis of PHC. p<0.001 The SF ≥ 300 ng/ml, PAIF ≥ 300 ng/ml for the diagnosis of PHC discriminant value, the results in each group in Table 2. The sensitivity, specificity, reliability, false positives, and false negatives of SF and PAIF in the diagnosis of PHC were: 79.49%, 69.23%, 65.91%, 86.89%, 65.9%, and 80%. , 47.73%, 1?