论文部分内容阅读
目的分析2例莫西沙星致心脏毒性并发神经系统不良反应的特点和规律,为临床合理用药提供依据。方法收集2010年1月—2012年12月2例莫西沙星致心脏毒性并发神经系统不良反应报告,从患者的性别、年龄、体重、既往史、药品名称、给药途径、不良反应的临床表现等方面进行统计、分析。结果共有2个案例患者发生上述不良反应。1例为中年子宫内膜炎口服用药患者,另1例为老年急性支原体肺炎静脉用药患者,均为初次常规剂量用药后1～2 h出现,且用药前均无变态反应史。后经停药或相关药物对症治疗后缓解恢复。结论临床使用莫西沙星应严格控制用药指征,预防为主,疗程不宜过长,用药初期严密监护,老年人应慎重用药,尽可能减少药品带来的伤害。
Objective To analyze the characteristics and regularities of 2 cases of moxifloxacin-induced cardiotoxicity complicated with nervous system adverse reactions, and to provide basis for clinical rational use of drugs. Methods A total of 2 cases of moxifloxacin-induced concurrent cardiotoxicity-induced adverse reactions were collected from January 2010 to December 2012. The data were collected from the patient’s gender, age, body weight, past history, drug name, route of administration and clinical manifestations of adverse reactions And other aspects of statistics, analysis. Results A total of 2 cases of patients with the above adverse reactions. One patient was middle-aged patients with oral endometritis, and the other patient was elderly patients with acute mycoplasma pneumoniae intravenous injection. All of them were presented 1 ~ 2 h after the first conventional dose and had no history of allergic reaction before treatment. After stopping or related drugs after symptomatic treatment to ease recovery. Conclusion Clinical use of moxifloxacin should be strictly controlled indications, prevention, treatment should not be too long, the initial intensive care, the elderly should be careful medication, as much as possible to reduce the harm caused by drugs.