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免疫核糖核酸(下称I-RNA)治疗肿瘤是一个有前途的方法。我们曾报道,从人脑胶质瘤中提取的碱性蛋白(GBP),在巨噬细胞电泳试验(MEM)中,能被脑瘤和各种恶性肿瘤病人的淋巴细胞所识别,并初步应用于临床脑瘤或其他恶性肿瘤的诊断。根据以上研究似可认为GBP是脑瘤和其他恶性肿脑的一种共同抗原。本文试图以GBP为抗原,致敏豚鼠,通过MEM证明:(1)GBP能否致使豚鼠体内引起细胞免疫反应;(2)从致敏豚鼠淋巴样组织中提取I-RNA能否超越种间界限传递给人的淋巴细胞具有这种抗GBP的
Immuno-ribonucleic acid (hereinafter referred to as I-RNA) is a promising method for treating tumors. We have reported that the basic protein (GBP) extracted from human gliomas can be recognized by lymphocytes from brain tumors and various malignant tumors in the macrophage electrophoresis test (MEM) and used initially. For the diagnosis of clinical brain tumors or other malignancies. Based on the above studies, GBP is considered to be a common antigen for brain tumors and other malignant tumors. This article attempts to use GBP as antigen, sensitized guinea pigs, through MEM to prove: (1) whether GBP can cause cellular immune response in guinea pigs; (2) whether extraction of I-RNA from guinea pig lymphoid tissue can exceed the boundary between species The lymphocytes passed to humans have this anti-GBP