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目的 :通过检测前胰岛素水平来探讨 2型糖尿病患者高胰岛素血症的原因。方法 :采用放射免疫分析法测定 2型糖尿病患者和正常对照组血浆前胰岛素 (PIM)、胰岛素 (IRI)和 C肽 (CP)水平。结果 :2型 DM组空腹 PIM(2 7.89± 2 2 .37pmol/ L)、IRI(186 .6 3± 136 .97pmol/ L)水平和 PM/ IRI比值 (17.11± 9.35 % )均明显高于对照组 PIM (6 .75± 5 .6 2 pmol/ L ) .IRI(10 7.6 7± 2 6 .43pm ol/ L )水平和 PIM/ IRI比值 (5 .6 7±3.6 6 % ) (P均 <0 .0 1) ;两组之间空腹 C P水平差异无显著性意义 (6 83.1± 5 87.4pm ol/ L比 5 2 8.0±2 0 1.3pm ol/ L,P>0 .0 5 )。结论 :2型糖尿病患者的高胰素血症主要是高前胰岛素血症所致 ,可能是胰岛素抵抗的原因之一。
Objective: To explore the causes of hyperinsulinemia in type 2 diabetic patients by detecting the level of proinsulin. Methods: Plasma insulin, insulin (IRI) and C-peptide (CP) levels in patients with type 2 diabetes mellitus and controls were measured by radioimmunoassay. Results: The levels of fasting PIM (2.789 ± 2.23pmol / L), IRI (186.363 ± 136.97pmol / L) and PM / IRI (17.11 ± 9.35%) in DM group were significantly higher than those in control The levels of PIM (6.75 ± 5.26 pmol / L) and IRI (10 7.6 7 ± 26.43 pmol / L) and PIM / IRI ratio (5.66 ± 3.6 6% 0. 01). There was no significant difference in fasting CP between the two groups (6 83.1 ± 5 87.4 pmol / L vs 52.08 ± 20 1.3 pmol / L, P> 0.05). Conclusion: Hypervisulinemia in type 2 diabetic patients is mainly caused by hyperinsulinemia and may be one of the causes of insulin resistance.