论文部分内容阅读
目的:探讨动脉粥样硬化患者胱硫醚酶基因多态性及其与临床的关联性。方法:在颈动脉超声检查的高血压患者中，随机抽取114例颈动脉中内膜增厚或斑块阳性的患者作为研究组，检测其身高、体重、血压、血脂、血糖、血尿酸、同型半胱氨酸(homocysteine，HCY)水平，并检测CBS基因G919A和T883C位点碱基，并与155例颈动脉正常的高血压患者作为对照组比较。结果:研究组体重指数、收缩压、总胆固醇、甘油三酯、空腹血糖、血尿酸、HCY水平高于对照组，差异有统计学意义(n P0.05)。血尿酸，收缩压和CBS基因T883C位点突变是颈动脉粥样硬化的独立危险因素(n P0.05)。颈动脉粥样硬化的高血压患者CBS基因T883C位点次等位基因突变率高。n 结论:颈动脉粥样硬化的高血压患者血压、血脂、血糖、血尿酸、HCY水平高、收缩压、血尿酸和CBS基因T883C位点多态性是颈动脉粥样硬化的独立危险因素，其CBS基因T883C次等位基因突变率高。“,”Objective:To investigate the Cystathionine-β-synthase (CBS) gene polymorphism in patients with atherosclerosis and its clinical relevance.Methods:114 hypertensive patients with carotid plaque based on ultrasonography were randomly selected as study group with 155 hypertensive patients without carotid plaque as control group. Height, weight, blood pressure, levels of blood lipid, blood glucose, blood uric acid and homocysteine (HCY), and polymorphism of CBS gene G919A and T883C loci were detected and compared between groups.Results:Patients in study group had significantly higher body mass index, systolic blood pressure, total cholesterol, triglyceride, fasting blood glucose, blood uric acid, and HCY levels than those in control group (n P<0.01 orn P0.05). Systolic blood pressure, uric acid and CBS T883C mutation are independent risk factors of carotid plaque (n P0.05). The frequency of both CBS G919A and T883C mutations were higher in hypertensive patients with carotid plaque, but only the difference in T883C mutation reached significance.n Conclusions:Hypertensive patients with carotid atherosclerosis have higher levels of blood pressure, blood lipid, blood glucose, uric acid and HCY and show higher frequency of CBS T883C mutation. Systolic pressure, uric acid and CBS T883C mutation are independent risk factors of carotid atherosclerosis.