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目的：探讨了乳腺癌患者手术治疗前后血清C A153、C A125、H c y和I L-8水平的变化及临床意义。方法：应用放射免疫分析法和免疫化学法对38例乳腺癌患者进行了手术治疗前后血清C A153、C A125、H c y和I L-8水平检测，并与35个正常健康人做比较。结果：乳腺癌患者在手术治疗前血清C A153、C A125、H c y和I L-8水平均非常显著地高于正常人组（P＜0.05），手术治疗3个月后则与正常人比较无显著性差异（P＞0.05），血清C A153水平与C A125、IL-8水平呈显著正相关（r=0.6028、0.5722、0.4986，P＜0.01）结论：检测乳腺癌患者手术治疗前后血清CA153、CA125、Hcy和IL-8水平的变化对观察病情和预后判定均具有重要的临床价值。“,”Objective: to explore the clinical significance of changes of serum CA153、CA125、Hcy and IL-8 levels after operation in patients with Breast cancer. Methods: serum CA153、CA125、IL-8 (with RIA) serum Hcy(with immune chemistry)levels were determined in 38 patients with Breast cancer and 35 controls . Result: Before operation serum CA153、CA125、Hcy and IL-8 levels were significantly higher than those in controls (P0.05). serum CA153 levels were positively correlated with serum CA125、Hcy、IL-8 levels(r=0.6028、0.5722、0.4986,P<0.01). Conclusions:Detection of serum CA153、CA125、Hcy and IL-8 levels after operation might be of prognostic importance in patients with Breast cancer.