登革病毒(Dengue virus,DENV)是登革热(DF)、登革出血热和登革休克综合征(DHF/DSS)的病原体。根据包膜蛋白的抗原性的不同,DENV可分为4个血清型,即DENV1～4。由于血清型比较复杂,目前关于病毒受体仍未得出明确一致的结论。但近几年取得了一些引人注目的进展,比如研究发现甘露糖受体(MR)、CLEC5A等作为DENV的受体,可能在病毒进入宿主细胞过程中发挥重要作用。为此,就近几年关于DENV受体以及病毒进入细胞的机制作一综述。 Dengue virus (DENV) is the causative agent of dengue fever (DF), dengue haemorrhagic fever and dengue shock syndrome (DHF / DSS). According to the antigenicity of the envelope protein, DENV can be divided into 4 serotypes, that is, DENV1 ~ 4. Due to the more complex serotypes, there is currently no clear consensus on the viral receptors. However, some remarkable progress has been made in recent years. For example, it has been found that mannose receptor (MR), CLEC5A and the like act as receptors for DENV and may play an important role in virus entry into host cells. To this end, in recent years on the DENV receptor and virus into the cell mechanism is reviewed.