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目的:探讨甲亢患者核素治疗后机体内环境的改变。方法:对明确诊断的甲亢患者行核素131I治疗,在治疗前检测患者体质指数(body mass index,BMI)、自然杀伤细胞(natural killer cell,NK)、肿瘤坏死因子(tumor necrosis factor,TNF)-α以及干扰素(interferon,IFN)-γ。选择治疗缓解的31例患者及未缓解的11例患者在治疗后6个月再次检测以上指标,并与40例健康体检者进行对照比较。结果:甲亢患者BMI、NK细胞低于对照组(P<0.05,P<0.01),TNF-α和IFN-γ显著高于对照组(均P<0.01);131I治疗6个月后,缓解组BMI、NK细胞已与对照组无显著性差异;TNF-α和IFN-γ出现降低,但依然显著高于对照组(均P<0.01),未缓解组BMI与对照组比较无显著性差异(P>0.05),其他指标均有显著性差异(均P<0.01)。结论:甲亢患者核素治疗后,机体内环境也在逐渐回稳,但依然落后于临床症状的改善,需更长时间的恢复或新的治疗策略。
Objective: To investigate the changes of the internal environment in patients with hyperthyroidism after radionuclide therapy. Methods: 131I treatment of patients with hyperthyroidism was performed. The body mass index (BMI), natural killer cell (NK), tumor necrosis factor (TNF) -α and interferon (IFN) -γ. Thirty-one patients who were selected for remission and 11 patients who did not remission were tested again at 6 months after treatment and compared with 40 healthy subjects. Results: The levels of BMI and NK cells in patients with hyperthyroidism were significantly lower than those in the control group (P <0.05, P <0.01), and the levels of TNF-α and IFN-γ in hyperthyroidism patients were significantly higher than those in the control group (all P <0.01) BMI, NK cells had no significant difference with the control group; TNF-αand IFN-γdecreased, but still significantly higher than the control group (all P <0.01); BMI in the non-remission group had no significant difference compared with the control group P> 0.05), other indicators were significantly different (all P <0.01). Conclusion: After the treatment of radionuclide in patients with hyperthyroidism, the internal environment of the hyperthyroidism is gradually stabilized, but still lag behind the improvement of clinical symptoms, requiring longer recovery or new treatment strategies.