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随着新化合物的不断合成以及新剂型、新的给药方式在临床的广泛应用,化学药物治疗已成为目前最常见和有效的肿瘤治疗方式之一。为寻求对肿瘤患者提供更合理的方式给药,20世纪90年代初期,有学者提出“缓释化疗”的概念,即将化疗药制备成具有缓释作用的给药系统,经不同方式注入肿瘤组织、瘤周组织的间质或肿瘤切除后的瘤床,以达到局部持久化疗的目的。缓释药物化疗可保证肿瘤局部具有较高的药物浓度和较长的药物维持时间,是抗癌化学药物给药途径的一个新的研究方向。
Chemotherapy has become one of the most common and effective oncology treatments with the continuous synthesis of new compounds and new dosage forms and new modes of delivery in clinical practice. In order to find a more reasonable way to administer cancer patients, in the early 1990s, some scholars proposed the concept of “sustained-release chemotherapy”, that is, the chemotherapeutic drugs were prepared into sustained-release drug delivery systems and injected in different ways Tumor, peritumoral tumor or tumor resection tumor bed, in order to achieve the purpose of local long-term chemotherapy. Sustained-release drug chemotherapy can ensure that the local tumor has a higher drug concentration and longer drug maintenance time, which is a new research direction of anticancer drug administration.