Objectivs For better understanding the incidence, clinical and pathological features of rapidlyprogressive glomerulonephritis and improving the level of diagnosis and treatent. Methods Records Of 19 biopsyproved RPGN were reviewed. Results Nephrotic syndrome and acute renal failure were common. The incidenceof this disease is about 2% of all renal biopsies of the same period. Conclusion 1. Renal biopsy should beperformed as soon as possible if RPGN is suspected. 2. The detection of antineutrophil cytoplasmic autoantibody isvery important. 3. The indication of pulse therapy should be strictly justified according to the pathologicalfindings. 4. Dialysis and plasma exchange should be given to ARF patients in the early stage. Objectivs For better understanding the incidence, clinical and pathological features of rapidly progressive glomerulonephritis and improving the level of diagnosis and treatent. Methods Records Of 19 biopsyproved RPGN were reviewed. Results Nephrotic syndrome and acute renal failure were common. The incidence of this disease is about 2% of all renal biopsies of the same period. Conclusion 1. The indication of pulse therapy should beperformed as soon as possible as possible if RPGN is suspected. 2. The detection of antineutrophil cytoplasmic autoantibody is very important. 3. The indication of pulse therapy should be strictly justified according to the pathologicalfindings. 4. Dialysis and plasma exchange should be given to ARF patients in the early stage.